Gastrointestinal Motility Modulating Drugs
نویسندگان
چکیده
منابع مشابه
Human prokinetic drugs promote gastrointestinal motility in zebrafish.
BACKGROUND Gastrointestinal (GI) motility disorders are highly prevalent in populations worldwide and the development of effective and safe drug treatments for GI motility disorders has proven challenging. In this study, taking advantage of the transparency of larval zebrafish, we developed a novel zebrafish GI motility model for drug screening and efficacy assessment. METHODS Zebrafish at 5 ...
متن کاملGastrointestinal Motility
Anatomic regions of the stomach are the fundus, corpus (body), antrum and pylorus. The functional regions of the stomach do not correspond to the anatomic regions. Functionally, the stomach can be divided into the gastric reservoir and the gastric pump (Fig. 1). The gastric reservoir consists of the fundus and corpus. The gastric pump is represented by the area at which peristaltic waves occur:...
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Gastrointestinal (GI) motility is an essential function of digestive and absorptive processes of the gut, required for propelling intestinal contents, mixing them with digestive juices, and preparing unabsorbed particles for excretion. Pivotal to the discussion of mechanisms for producing defined patterns of motor responses are important and intimately related aspects of intestinal neurophysiol...
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The Gastrointestinal Motility Monitor (GIMM; Catamount Research and Development; St. Albans, VT) is an in vitro system that monitors propulsive motility in isolated segments of guinea pig distal colon. The complete system consists of a computer, video camera, illuminated organ bath, peristaltic and heated water bath circulating pumps, and custom GIMM software to record and analyze data. Compare...
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Relaxin is involved in a variety of functions. Among them, relaxin influences gastrointestinal motility in mice mainly regulating the biosynthesis of nitric oxide, considered as the main substance causing smooth muscle relaxations. Relaxin is able to regulate the different nitric oxide synthase expression depending on the gut region considered. Relaxin also counteracts the hypermotility state, ...
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ژورنال
عنوان ژورنال: Journal of the Korean Medical Association
سال: 2009
ISSN: 1975-8456
DOI: 10.5124/jkma.2009.52.9.920